VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide the body makes to calm inflammation and keep the immune system, blood vessels, and hormones in balance. Researchers care about it as the final-stage agent in the Shoemaker CIRS (mold/biotoxin illness) protocol, where it is studied for restoring regulatory neuropeptide function after the upstream steps are complete. Supplied as lyophilized 5 mg and 10 mg vials for research use; compounded VIP is not FDA-evaluated.
- A 28-amino-acid neuropeptide with broad anti-inflammatory, immune-regulating, and vasoactive effects.Peptide Guide p.112
- In the Shoemaker CIRS protocol it is the final-stage agent, used to restore regulatory neuropeptide function.Peptide Guide p.112
- The guide's what-to-expect note: improved inflammatory markers, energy, and quality of life in CIRS when used at the end of the protocol, and not as a standalone fix.Peptide Guide p.112
- Sequence is the whole game: the protocol gates it behind a VCS pass and MARCoNS clearance, and out-of-order use can backfire.Shoemaker CIRS protocol
- Tracked against the CIRS marker panel the guide lists per Shoemaker: TGF-beta1, C4a, MMP-9, and VIP level.Peptide Guide p.112