NAD+ is the coenzyme that keeps cells running: a participant in more than 500 enzyme reactions and the substrate for sirtuins and PARP DNA repair. Levels drop by roughly half between age 20 and 50. The guide describes the injectable form as achieving levels precursor supplements cannot, while noting there is no SubQ outcomes trial.
- NAD+ declines by about 50% between age 20 and age 50.Peptide Guide (PubMed)
- Acts as a coenzyme in over 500 separate enzyme reactions.Peptide Guide (PubMed)
- Serves as the substrate for sirtuins (epigenetic repair) and PARP (DNA repair), the two systems that clean up cellular damage.Peptide Guide (PubMed)
- Powers ATP production, the cell's working energy currency.Peptide Guide (PubMed)
- The injectable form reaches levels precursor supplements cannot, though human data comes from oral precursors (NR/NMN) or IV, with no SubQ outcomes trial.Peptide Guide (evidence note)