DSIP, Delta Sleep-Inducing Peptide, is a naturally occurring peptide studied for pushing sleep toward the deep slow-wave stage. It modulates CRH, with reduced overnight stress hormones and circadian regulation as the reported effects. The mechanism is genuinely interesting, the human evidence is still thin, and the source guide is blunt about both.
- Promotes slow-wave (delta) sleep and helps regulate circadian rhythm.PubMed: DSIP
- Modulates CRH, with reduced overnight cortisol as the reported signal.PubMed: DSIP
- Reported effects appear early rather than after weeks of buildup: deeper, more restorative sleep, plus vivid dreams in some subjects.Peptide Guide, expected effects
- Straight talk: human data are minimal and no dosing RCT exists.Peptide Guide, evidence note
- PCAC rejected it (as "emideltide") from the 503A bulks list 6 to 7 in July 2026, the only one of seven peptides voted down.PCAC vote, Jul 2026