CJC-1295 (No DAC) is a GHRH analog that binds GHRH receptors on pituitary somatotrophs and produces natural pulsatile GH release. The short half-life is the point: roughly a 30-minute pulse, which is why it is the canonical GHRH half of GHRH plus GHRP research stacks.
- Binds GHRH receptors on pituitary somatotrophs, producing natural pulsatile GH release.PubMed: CJC-1295 (No DAC)
- Short half-life gives a clean GH pulse of roughly 30 minutes.Peptide Guide p. 27
- GHRH receptor signaling saturates at low concentrations, so GH output plateaus rather than scaling with concentration.Peptide Guide p. 27
- Reported effect timeline: sleep quality at 1-2 weeks, recovery at 4-6 weeks, body-composition change at 8-12 weeks.Peptide Guide p. 27
- The canonical GHRH plus GHRP pairing is with ipamorelin; IGF-1 LR3 is the usual downstream-amplification partner in research stacks.Peptide Guide p. 27