Kisspeptin-10 sits at the very top of the reproductive axis. It activates GPR54 in the hypothalamus, which releases GnRH, which sets off an LH and FSH surge, which ends in testosterone, so the whole cascade runs on the body's own machinery instead of replacing it. Human data exists, and the response curve has a twist that keeps researchers interested.
- Activates GPR54 in the hypothalamus, releasing GnRH and triggering an LH and FSH surge that ends in testosterone.PubMed: Kisspeptin-10
- In females the LH and FSH response is hugely cycle-dependent, reported as over 100 times stronger just before ovulation.The Complete Peptide Guide p.53
- Human data (George 2011) found the LH response peaks at low exposure, with higher exposure producing a weaker response rather than a bigger one.George 2011, human data
- In males the literature reports raised LH and testosterone and faster LH pulses, and it is investigational for low testosterone and low libido.PubMed: Kisspeptin-10
- GPR54 desensitizes under continuous exposure, which makes the receptor's pulse dependence a central question in the research.The Complete Peptide Guide p.53